Joining the Raiders midway through the 1987 season, Jackson rushed for 554 yards on 81 carries in just seven games. Over the next three seasons, Bo Jackson would rush for 2,228 more yards and 12 touchdowns: a remarkable achievement, in light of the fact that he was a "second string" player behind Marcus Allen.
Jackson turned in a 221-yard rushing performance on Monday Night Football in 1987 against the Seattle Seahawks. During this game, he ran over Seahawks linebacker Brian Bosworth, who had insulted Jackson and promised in a media event before the game to contain Jackson. He also made a 91-yard run to the outside, untouched down the sideline. He continued sprinting until finally slowing down as he passed through the entrance to the field tunnel to the dressing rooms with teammates soon following. Jackson scored two rushing touchdowns and one receiving touchdown in the game.
In his four seasons in the NFL, Jackson rushed for 2,782 yards and 16 touchdowns with an average yards per carry of 5.4. He also caught 40 passes for 352 yards and two touchdowns. Jackson's 221 yards on November 30, 1987, just 29 days after his first NFL carry, is still a Monday Night Football record.